Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nuclear lamins: building blocks of nuclear structure and function.

Robert D Goldman1, Anne E Goldman, Dale K Shumaker

  • 1Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611-3008, USA.

Novartis Foundation Symposium
|March 19, 2005
PubMed
Summary

Nuclear lamins form a 3D network within the cell nucleus, providing essential infrastructure for DNA replication and transcription. This nucleoskeleton supports the dynamic assembly of crucial nuclear functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell-matrix interaction in 3D.

Biophysical journal·2026
Same author

Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D.

bioRxiv : the preprint server for biology·2025
Same author

Vimentin intermediate filaments as structural and mechanical coordinators of mesenchymal cells.

Nature cell biology·2025
Same author

Vimentin undergoes liquid-liquid phase separation to form droplets which wet and stabilize actin fibers.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture.

PNAS nexus·2024
Same author

Vimentin filaments integrate low-complexity domains in a complex helical structure.

Nature structural & molecular biology·2024

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The cell nucleus lacks membrane-bound compartments, necessitating internal organization for complex functions.
  • Nuclear processes like DNA replication and transcription involve dynamic, multi-component complexes.
  • Nuclear lamins are implicated as key structural components of the nuclear architecture.

Purpose of the Study:

  • To investigate the role of nuclear lamins in essential nuclear processes.
  • To test the hypothesis that lamins form a 3D nucleoplasmic network.
  • To understand how this network supports the assembly of functional complexes.

Main Methods:

  • The abstract does not specify methods, but implies investigations into nuclear structure and function.
  • Focus on observing the spatial and temporal dynamics of nuclear components.

Related Experiment Videos

  • Analysis of nuclear lamins' contribution to nuclear architecture.

    • Main Results:

    • Evidence suggests nuclear lamins are vital for nuclear infrastructure.
    • Lamins' proper assembly and organization are crucial for nuclear functions.
    • The proposed lamin network provides a framework for nuclear complex assembly.

    Conclusions:

    • Nuclear lamins form an essential 3D nucleoplasmic network.
    • This lamin infrastructure is critical for organizing and facilitating DNA replication and transcription.
    • The nucleoskeleton, including lamins, is fundamental to nuclear architecture and function.