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Updated: Aug 19, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Treatment of OSAS with modified twin-block advancement appliances]
Pei-zeng Jia1, Min-kui Fu, Xiang-long Zeng
1Department of Orthodontics, Peking University School of Stomatology, Beijing 100081, China. jiapeiz@sina.com
Objective:
To introduce a new modified twin-block advancement appliance and investigate the effects on respiratory variables in patients with OSAS.
Methods:
29 patients with OSAS participated in the study and were fitted with modified twin-block appliances to hold the mandible in an anterior and inferior position. Polysomnography was performed with and without appliance insertion. And questionnaires were used for registration of patients subjective symptoms. Pair-t analysis was used to evaluate the effects of appliances in patients with OSAS.
Results:
26 patients responded to the appliance therapy. Apnea-hypopnea index, apnea index and hypopnea index were reduced significantly (P < 0.01). Lowest arterial oxygen saturation improved significantly (P < 0.01). Discomfort with mandibular advancement disappeared within one week.
Conclusions:
Modified twin-block advancement appliance is a conservative, successful treatment alternative that could benefit patients suffered from OSAS.
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