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Updated: Aug 19, 2026
Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome
Published on: June 2, 2022
[The effect of body position changes on lung function, lung CT imaging and pathology in an oleic acid-induced acute
Xin-ping Ji1, Yu-zhi Wang, Li-li Yang
1Department of Emergency, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
Objective:
To study the effect of body position changes on lung mechanics, oxygenation, CT images and pathology in an oleic acid-induced acute lung injury (ALI) model.
Methods:
The study groups consisted of one control group and three experimental groups in which the rabbits were put on supine, prone and rotation, respectively. The changes of partial pressure of arterial oxygen (PaO(2)), lung mechanics in the course of the experiment, as well as lung CT and pathology were observed and analyzed.
Results:
PaO(2) and lung compliance of the prone and the rotation rabbits were higher than those of the supine rabbits [(158 +/- 51) mm Hg, (166 +/- 37) mm Hg, (87 +/- 24) mm Hg; (2.8 +/- 0.9) ml/cm H(2)O, (2.6 +/- 0.7) ml/cm H(2)O, (1.6 +/- 0.5) ml/cm H(2)O, respectively, all P < 0.05], while intrapulmonary shunt was significantly less in the prone and the rotation groups. The airway peak inspiration pressure of the rotation rabbits was higher than that of the prone rabbits [(20 +/- 2) cm H(2)O, (16 +/- 2) cm H(2)O, P < 0.05]. PaO(2) was positively correlated to the lung compliance and negatively correlated to the intrapulmonary shunt. Oleic acid-induced ALI lung CT was divided into dependent region and nondependent region, and the CT changes of the two regions were rapid after position change. The distribution of lung edema was affected by gravitation.
Conclusions:
Prone and rotation positions can improve oxygenation in this ALI model. Continuous rotation can relieve the extent of compressive lung collapse which occurs in ALI.
