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Interactions between bacteria and Candida in the burn wound
Nivedita Gupta1, Absarul Haque, Gauranga Mukhopadhyay
1Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Summary
Pseudomonas species inhibit the growth of Candida species in burn wound infections. This bacterial interaction explains the absence of Candida in wounds where Pseudomonas is present.
Area of Science:
- Medical Microbiology
- Clinical Mycology
- Wound Infections
Background:
- Burn wounds are susceptible to polymicrobial infections.
- Candida species are common fungal pathogens in burn wound infections.
- The role of bacterial-fungal interactions in burn wound pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the effect of bacterial species commonly found in burn wounds on the growth of Candida species.
- To determine if specific bacteria can inhibit Candida growth in vitro.
Main Methods:
- Analysis of 300 burn patient samples over two years.
- Culturing of bacterial species from burn wounds.
- In vitro assessment of bacterial species' effect on Candida species growth on Sabouraud dextrose agar (SDA) slants.
Main Results:
- Pseudomonas species, whether alone or in combination with other bacteria, consistently inhibited the growth of Candida species.
- A significant negative correlation was observed between the presence of Pseudomonas species and Candida species in burn wound samples.
Conclusions:
- Pseudomonas species possess inhibitory properties against Candida species growth.
- The presence of Pseudomonas species is a likely reason for the absence of Candida species in polymicrobial burn wound infections.