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Depression in multiple sclerosis: a review.

R J Siegert1, D A Abernethy

  • 1Rehabilitation Teaching and Research Unit, Department of Medicine, Wellington School of Medicine, University of Otago, PO Box 7343, Wellington South, New Zealand. rsiegert@wnmeds.ac.nz

Journal of Neurology, Neurosurgery, and Psychiatry
|March 19, 2005
PubMed
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Depression is common in multiple sclerosis (MS), affecting up to 50% of patients. This review examines MS depression, its causes, and effective treatments for improved patient outcomes.

Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Medicine

Background:

  • Multiple sclerosis (MS) is frequently associated with high rates of depression.
  • Lifetime prevalence of depression in MS approximates 50%, with annual prevalence around 20%.

Purpose of the Study:

  • To review the current understanding of depression in MS.
  • To identify key issues and research priorities concerning MS and depression.

Main Methods:

  • Literature review and critical commentary on existing studies.
  • Focused on specific questions regarding depression prevalence, CNS lesions, suicide risk, anxiety, fatigue, cognitive impairment, psychosocial factors, interferon treatment, and treatment efficacy.

Main Results:

  • Depression is a significant comorbidity in MS.

Related Experiment Videos

  • The review addresses the relationship between MS, depression, and various associated factors including neurological lesions, fatigue, cognitive changes, and psychosocial influences.

    • Conclusions:

    • Depression is a prevalent and complex issue in multiple sclerosis.
    • Further research is needed to understand and effectively treat depression in MS patients.