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Updated: Aug 19, 2026

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
Published on: March 19, 2021
Syndecans: new kids on the signaling block
Eugene Tkachenko1, John M Rhodes, Michael Simons
1Angiogenesis Research Center, Section of Cardiology, and Department of Medicine, Dartmouth Medical School, Lebanon, NH, USA.
Abstract:
Cell-associated proteoglycans provide highly complex and sophisticated systems to control interactions of extracellular cell matrix components and soluble ligands with the cell surface. Syndecans, a conserved family of heparan- and chondroitin-sulfate carrying transmembrane proteins, are emerging as central players in these interactions. Recent studies have demonstrated the essential role of syndecans in modulating cellular signaling in embryonic development, tumorigenesis, and angiogenesis. In this review, we focus on new advances in our understanding of syndecan-mediated cell signaling.
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