Related Experiment Video
Updated: Aug 19, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
Published on: June 24, 2018
[Mechanism of PTH actions on bone]
1Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine.
None:
PTH acts on the osteoblast and regulates bone resorption and formation. While a continuous increase in circulating PTH results in bone loss due to predominantly enhanced bone resorption, intermittent PTH treatment strongly stimulates bone formation and thereby increase bone mass. PTH has divergent effects on the osteoblast, regulating its proliferation, differentiation and survival. Although some evidence suggest an involvement of transcription factors such as fos family and local factors including IGF-1, mechanisms by which PTH stimulates bone formation remain largely unknown.
Related Concept Videos
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Skeleton and Calcium Homeostasis
Bone Remodeling
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Osteoclasts in Bone Remodeling
Roles of Electrolytes: Calcium and Phosphate
The calcium concentration in blood plasma is primarily regulated...
