Related Experiment Video
Updated: Aug 19, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
[The intracellular signal transduction systems of PTH and its effects on bone resorption and formation]
Hiroshi Kaji1, Toshitugu Sugimoto
1Division of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine.
Abstract:
PTH binds to PTH/PTHrP receptor, one of seventh transmembrane receptor, which activates cAMP/PKA system through Gs protein and causes an activation of PKC and an elevation of cytosolic calcium through Gq protein. PTH affects bone cells through these dual second messenger signaling systems(cAMP/PKA and Ca/PKC system). Recent studies revealed that PTH stimulates bone resorption as well as bone formation mainly through cAMP/PKA system. Further work is necessary to clarify the downstream of the signal, such as CREB and AP-1.
Related Concept Videos
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling
Skeleton and Calcium Homeostasis
Osteoclasts in Bone Remodeling
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Roles of Electrolytes: Calcium and Phosphate
The calcium concentration in blood plasma is primarily regulated...
