Related Experiment Video
Updated: Aug 19, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
[Atherosclerosis and bisphosphonate]
1Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine.
Abstract:
Bisphosphonates are widely used for the treatment of osteoporosis, hypercalcemia, Paget's disease, and osteolytic disease due to malignant tumor or its metastasis. Certain compounds of bisphosphonates have been shown to inhibit the development of experimental atherosclerosis without altering serum lipid profile. Recently, etidronate has been demonstrated to prevent the thickening of carotid arterial wall in diabetic patients associated with osteopenia. These findings may illuminate clinical application of bisphosphonates for the treatment of atherosclerosis and vascular calcification.
Related Concept Videos
Atherosclerosis I: Introduction
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Atherosclerosis III: Management
Atherosclerosis IV: Nursing Management
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Peripheral Artery Disease I: Introduction
