Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Differentiation of osteoclasts].

Takahisa Sasaki1

  • 1Department of Oral Histology, Showa University School of Dentistry.

Clinical Calcium
|March 19, 2005
PubMed
Summary
This summary is machine-generated.

Receptor activator of NF-kappaB ligand (RANKL) promotes osteoclast formation and function, while osteoprotegerin (OPG) inhibits these processes. OPG also induces osteoclast apoptosis, highlighting its regulatory role in bone resorption.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain.

G3 (Bethesda, Md.)·2021
Same author

Spinal anesthesia for muscle biopsy in an infant with a suspected neuromuscular disorder: a case report.

JA clinical reports·2020
Same author

Identification and characterization of the precursors committed to osteoclasts induced by TNF-related activation-induced cytokine/receptor activator of NF-kappa B ligand.

Journal of immunology (Baltimore, Md. : 1950)·2006
Same author

Differentiation and function of osteoclasts cultured on bone and cartilage.

Journal of electron microscopy·2006
Same author

Effects of osteoprotegerin administration on osteoclast differentiation and trabecular bone structure in osteoprotegerin-deficient mice.

Journal of electron microscopy·2005
Same author

Osteoclast differentiation at growth plate cartilage-trabecular bone junction in newborn rat femur.

Journal of electron microscopy·2004

Area of Science:

  • Bone biology and skeletal physiology.
  • Cellular and molecular mechanisms of bone remodeling.

Context:

  • Osteoclast (OC) differentiation and function are critical for bone homeostasis.
  • Key regulatory factors include osteoblast-derived signals like receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG).

Purpose:

  • To elucidate the specific roles of RANKL and OPG in osteoclastogenesis and function.
  • To investigate the molecular mechanisms by which OPG modulates osteoclast activity and survival.

Summary:

  • RANKL stimulates the differentiation of preosteoclasts (pOCs) into mature, resorptive osteoclasts (TRAP-positive, expressing vacuolar-type H(+)-ATPase).
  • OPG effectively inhibits RANKL-induced osteoclastogenesis and resorptive activity.
  • OPG further suppresses mature osteoclast function by inhibiting ruffled border formation, reducing resorption, and inducing apoptosis.

Related Experiment Videos

Impact:

  • Provides a detailed understanding of the RANKL/OPG signaling pathway in bone remodeling.
  • Highlights OPG as a potent inhibitor of osteoclast activity, with implications for bone diseases characterized by excessive resorption.