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Updated: Aug 10, 2026
14:55
Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
Published on: June 24, 2018
[Osteopontin: a topic from the point of bone morphology]
Masaki Noda1, Kunikazu Tsuji, Akira Nifuji
1Department of Molecular Pharmacology Medical Research Institute, Tokyo Medical and Dental University.
Clinical Calcium
|March 19, 2005
Summary
Osteopontin, a key bone matrix protein, plays a crucial role in bone remodeling. Its RGDS motif facilitates cell attachment and integrin activation, influencing bone turnover.
Area of Science:
- Biochemistry
- Cell Biology
- Bone Biology
Context:
- Osteopontin is a major non-collagenous protein in the bone matrix, comprising about 10% of these proteins.
- Its structure features an RGDS motif essential for cell adhesion and integrin activation.
- High levels of osteopontin are found in osteoclasts and vascular structures.
Purpose:
- To elucidate the structural and functional significance of osteopontin in bone matrix.
- To investigate the role of osteopontin in cell attachment and integrin signaling.
- To explore osteopontin's involvement in the regulation of bone turnover.
Summary:
- Osteopontin, a significant non-collagenous bone matrix protein, contains an RGDS motif crucial for cell attachment and integrin activation, particularly the alpha v beta 3 integrin.
- This protein is highly concentrated in the lamina limitans and cement line of bone.
- These findings suggest osteopontin's involvement in initiating and terminating bone remodeling processes.
Impact:
- Provides insights into the molecular mechanisms underlying bone remodeling.
- Highlights osteopontin as a potential target for therapeutic interventions in bone diseases.
- Enhances understanding of cell-matrix interactions in the bone microenvironment.
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