Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Therapeutic approaches to increased bone resorption].

Teruki Sone1

  • 1Department of Nuclear Medicine, Kawasaki Medical School.

Clinical Calcium
|March 19, 2005
PubMed
Summary

Accelerated bone resorption drives diseases like osteoporosis. Understanding osteoclast mechanisms offers new ways to develop bone resorption inhibitors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of 3D-DXA-derived proximal femur measurements against QCT across international clinical cohorts.

Bone·2026
Same author

Effects of two exercise modalities and subsequent detraining on trabecular bone microarchitecture in growing male rats.

Physiological reports·2026
Same author

Correction: Risk factors for incident vertebral fractures in osteoporosis pharmacotherapy: a 2-year, prospective, observational study.

Journal of bone and mineral metabolism·2024
Same author

The effects of abaloparatide on hip geometry and biomechanical properties in Japanese osteoporotic patients assessed using DXA-based hip structural analysis: results of the Japanese phase 3 ACTIVE-J trial.

Archives of osteoporosis·2023
Same author

Abaloparatide dose-dependently increases bone mineral density in postmenopausal women with osteoporosis: a phase 2 study.

Journal of bone and mineral metabolism·2023
Same author

Effect of Bone Resorption Inhibitors on Serum Cholesterol Level and Fracture Risk in Osteoporosis: Randomized Comparative Study Between Minodronic Acid and Raloxifene.

Calcified tissue international·2023

Area of Science:

  • Bone biology and disease pathology
  • Molecular mechanisms of osteoclast function

Context:

  • Accelerated bone resorption is central to diseases including osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and rheumatoid arthritis-associated bone inflammation.
  • Existing antiresorptive agents are used to manage bone resorption in these conditions.

Purpose:

  • To highlight the significance of accelerated bone resorption in various bone diseases.
  • To underscore the potential for novel therapeutic strategies based on recent molecular insights.

Summary:

  • Osteoclast-mediated bone resorption is a key factor in the pathology of numerous skeletal disorders.
  • Current treatments focus on antiresorptive agents to control excessive bone breakdown.
  • Emerging knowledge of osteoclastic molecular pathways presents new avenues for drug development.

Impact:

  • Provides a foundation for developing targeted therapies for bone diseases.
  • Emphasizes the importance of understanding molecular mechanisms for therapeutic innovation in bone resorption.
  • Contributes to the ongoing search for more effective treatments for conditions characterized by bone loss or damage.

Related Experiment Videos