Related Experiment Video
Updated: Aug 10, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Relationship between estrogen-receptor genotype and tooth loss in postmenopausal women]
1Department of Oral & Maxillofacial Radiology, Hiroshima University Dental Hospital.
Abstract:
Tooth loss is known to be influenced by environmental factors, but the role of genetic factors remains unknown. It is likely that the estrogen-receptor (ER) gene could be associated with tooth loss in women because recent studies in the United State reported the protective effect of estrogen replacement therapy on tooth retention in the elderly. We first demonstrated relationship between ER genotype and tooth loss in post-menopausal women. However, further investigation is necessary to clarify unknown pathways in which ER genotype contributes to tooth loss in women.
Related Concept Videos
Oogenesis
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Menopause

