[Clinical application of bisphosphonates, present and future]
Related Experiment Video
Updated: Aug 13, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 9, 2014
1Metabolism , Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine.
Abstract:
For the present, bisphosphonates are widely applicable;secondary osteoporosis, metastatic bone diseases, primary hyperparathyroidism, osteogenesis imparfecta, inflammatory bone and joint disorders besides primary osteoporosis, hypercalcemia of malignancy, Paget's disease of bone, and so on. More expansion of its clinical application in the future is greatly expected with elucidation of the mechanism of action.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Osteoclasts in Bone Remodeling
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

