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Updated: Aug 19, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
[Application of calcium phosphate bone paste to fracture treatment]
1Department of Orthopaedic Surgery, Osaka City General Hospital.
Abstract:
Calcium phosphate bone paste (Biopex) is a viscous and injectable bioactive ceramic. The final maximum compressive strength is 80-90 Mpa, which is much higher than that of cancellous bone and slightly lower than that of cortical bone. Filling cancellous bone defects with this material could stabilize metaphyseal fractures in patients with osteoporosis and prevent subsequent reduction loss. Applications of this material to various fracture treatments have been reported and it was demonstrated that this material is useful if some complications are carefully avoided. Further studies are needed to determine the most suitable method for individual fractures to maximize the benefit and minimize the adverse effects.
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