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[Bone metabolism in androgen receptor-deficient mice]
Hirotaka Kawano1, Hiroshi Kawaguchi, Shigeaki Kato
1Department of Orthopaedic Surgery, Graduate School of Medicine, University of Tokyo.
Clinical Calcium
|March 19, 2005
Abstract
None:
Although the physiological significance of estrogen receptor function on skeletal tissues has been established, that of androgen receptor (AR) function has remained unclear. We show here that inactivation of AR in mice using a Cre-loxP system-mediated gene targeting technique caused bone loss in males, but not in females, which indicated that AR function is indispensable for male-type bone formation and remodeling.