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Updated: Aug 19, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
[Nerve distribution in synovium of osteoarthritic knees]
Tomoyuki Saito1, Tomihisa Koshino
1Department of Orthopaedic Surgery, Yokohama City University School of Medicine.
Abstract:
Neural elements are widely distributed in synovium of osteoarthritic knees. In medial compartmental osteoarthritic knees, medial synovium is exposed to mechanical stimuli due to osteophytes and lateral thrust, which may accumulate neuropeptides, especially substance P, in free nerve endings. Free nerve endings containing a large amount of substance P may provoke pain sensation in synovium, and release substance P to the surrounding tissue in subsynovial tissue, which induces synovitis. Neural system may modulate synovitis as well as pain pathway in osteoarthritis of the knee.
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