[Structure and function of T-type calcium channels]
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Updated: Aug 19, 2026

Analysis of Tubular Membrane Networks in Cardiac Myocytes from Atria and Ventricles
Published on: October 15, 2014
Hironao Saegusa1, Yoshihiro Matsuda, Tsutomu Tanabe
1Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University/ CREST, Japan Science and Technology Corporation.
Abstract:
Molecular structure of the T-type Ca(2+) channel was first clarified by the cloning of Ca(V)3.1 (alpha(1G)) as an authentic component of the T-type channel. Since then, much progress has been made in understanding functions of the T-type Ca(2+) channels, because it has become possible to study structure-function relationship for the T-type channel using mutagenesis techniques and to examine abnormal phenotypes of T-type channel knock-out mice. Here we will review briefly the recent progress in studies on structure and function of T-type Ca(2+) channels.
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