[ED-71]
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Updated: Aug 16, 2026

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice
Published on: February 9, 2013
1Chugai Pharmaceutical Co., Ltd.
Abstract:
ED-71 is a potent analog of active vitamin D, 1,25 (OH) (2)D(3), bearing a hydroxypropoxy substituent at the 2beta-position. In ovariectomized rats, ED-71 prevented the reduction in bone mass and strength of lumber spine without causing hypercalcemia. From those results, it was suggested that ED-71 preferentially enhances bone formation with less effects on intestinal calcium absorption. In osteoporotic patients, oral daily administration of ED-71 (0.25, 0.5, 0.75 and 1.0 microg) for 6 months increased bone mineral density (BMD) at L(2-4) in a dose-dependent manner. ED-71 also exhibited a dose-depend suppression of urinary deoxypyridinoline with no significant reduction in serum osteocalcin. These results demonstrate that ED-71 can effectively increase bone mass without causing hypercalcemia, and suggest that ED-71 can be a promising candidate for the treatment of osteoporosis with prominent effect on bone formation.
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