[Phosphate removal in hemodialysis therapy]

The control of plasma phosphate concentration in a dialysis patient is important to prevent some bone diseases. There are, however, few studies for phosphate kinetics in dialysis patients. Although molecular weight of phosphatic ion, mainly exists in the intravascular compartment, is relatively low, removal dynamics of phosphatic ion from the patient by the hemodialysis treatment is not simple. A tendency of relatively lower reduction rate of plasma phosphate concentration with higher clearance of the dialyzer, therefore, was often shown in a typical dialysis patient. Establishment of a detailed kinetic modeling involving phosphate generation and transport between intra and extra vascular compartments is required for the phosphate dynamics during the dialysis treatment.