Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Calcium dynamics in skeletal muscle].

N Kurebayashi1, Y Ogawa

  • 1Department of Pharmacology, Juntendo University School of Medicine.

Clinical Calcium
|March 19, 2005
PubMed
Summary

Skeletal muscle has two calcium (Ca2+) homeostasis systems: short-term internal shifts and long-term cellular content changes. Store-operated calcium entry, crucial in other cells, is now identified in skeletal muscle, exceeding L-type channel influx.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Doxorubicin alters Ca(2+) transients but fails to change Ca(2+) sensitivity of contractile proteins.

Environmental toxicology and pharmacology·2011
Same author

Depletion of Ca2+ in the sarcoplasmic reticulum stimulates Ca2+ entry into mouse skeletal muscle fibres.

The Journal of physiology·2001
Same author

Putative roles of type 3 ryanodine receptor isoforms (RyR3).

Trends in cardiovascular medicine·2001
Same author

Role of Mg(2+) in Ca(2+)-induced Ca(2+) release through ryanodine receptors of frog skeletal muscle: modulations by adenine nucleotides and caffeine.

Biophysical journal·2000
Same author

Abnormal features in skeletal muscle from mice lacking mitsugumin29.

The Journal of cell biology·1999
Same author

Ryanodine receptor isoforms in excitation-contraction coupling.

Advances in biophysics·1999

Area of Science:

  • Physiology
  • Cell Biology
  • Muscle Physiology

Context:

  • Skeletal muscle calcium (Ca2+) homeostasis is vital for muscle function.
  • Two distinct Ca2+ regulation mechanisms exist: short-term intracellular shifts and long-term extracellular balance.
  • The mechanisms governing Ca2+ influx and efflux in skeletal muscle remain incompletely understood.

Purpose:

  • To investigate the role and characteristics of calcium (Ca2+) homeostasis in skeletal muscle.
  • To explore the presence and significance of store-operated calcium entry in skeletal muscle cells.
  • To compare Ca2+ influx pathways in skeletal muscle.

Summary:

  • Skeletal muscle exhibits both short-term (intracellular Ca2+ dynamics during excitation-contraction coupling) and long-term (extracellular Ca2+ concentration-dependent cellular content) calcium homeostasis.
  • The study identifies store-operated calcium entry, a pathway previously recognized in non-excitable cells, within skeletal muscle.
  • This identified influx pathway is suggested to be more substantial than Ca2+ influx mediated by L-type voltage-gated calcium channels.

Impact:

  • This research enhances understanding of skeletal muscle calcium regulation.
  • It highlights the functional relevance of store-operated calcium entry in muscle physiology.
  • Findings may inform future research on muscle disorders related to calcium dysregulation.

Related Experiment Videos