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[Drugs that modulate the cellular function of calcium ion]
1Department of pharmacology, Gunma University School of Medicine.
Clinical Calcium
|March 19, 2005
Summary
Cellular calcium (Ca2+) signaling is crucial for cell function. This review summarizes drugs targeting proteins involved in calcium regulation, impacting cellular responses to stimuli.
Area of Science:
- Biochemistry
- Cell Biology
- Pharmacology
Context:
- Cytoplasmic calcium (Ca2+) concentration is tightly regulated at approximately 10(-7)M.
- Increases in Ca2+ concentration, triggered by stimuli, activate Ca2+-binding proteins and downstream signaling pathways.
- These pathways mediate cellular responses to various external signals.
Purpose:
- To review the effects of drugs targeting key proteins in calcium homeostasis and signaling.
- To provide a comprehensive overview of pharmacologic interventions affecting calcium-binding proteins.
Summary:
- This report focuses on drugs targeting proteins essential for maintaining low cytoplasmic Ca2+ levels.
- It examines the impact of these drugs on Ca2+ pumps, ion exchangers, ion channels, calmodulin, and other Ca2+-binding proteins.
- The review consolidates information on how these drug targets modulate cellular responses.
Impact:
- Understanding these drug targets is vital for developing novel therapeutics for diseases involving calcium dysregulation.
- This summary aids researchers in identifying potential pharmacological strategies for modulating cellular signaling pathways.
- The findings contribute to the broader knowledge of calcium's role in physiology and disease.