Related Experiment Videos
Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms
P Capaccio1, F Ottaviani, V Cuccarini
1Clinica Otorinolaringoiatrica, Azienda Ospedaliera L. Sacco; Polo Universitario Vialba, Ospedale Maggiore IRCCS, Milan, Italy.
Summary
Methylenetetrahydrofolate reductase (MTHFR) gene variations are linked to sudden hearing loss (SHL). These MTHFR gene polymorphisms may increase the risk of SHL by affecting vascular function.
Area of Science:
- Genetics
- Otolaryngology
- Cardiovascular Medicine
Background:
- Sudden hearing loss (SHL) can stem from vascular issues affecting the cochlea.
- Inherited prothrombotic factors are implicated in vascular impairment.
- Genetic factors are increasingly considered in SHL pathogenesis.
Purpose of the Study:
- To investigate the association between SHL and specific MTHFR gene polymorphisms (677 and 1298).
- To explore the role of MTHFR gene variations in the vascular underpinnings of SHL.
Main Methods:
- DNA genotyping was conducted on peripheral blood leukocytes.
- The study included 45 patients diagnosed with SHL and 135 healthy controls.
Main Results:
- Wild-type MTHFR (677CC/1298AA) was more common in controls (P=0.01).
- MTHFR gene polymorphisms (677CT, 677TT, 1298AC, 1298CC, and compound variants) were significantly more prevalent in SHL patients (P=0.005; Ptrend=0.001).
Conclusions:
- MTHFR gene polymorphisms appear to be potential risk factors for SHL.
- These genetic variations may contribute to vascular impairment associated with SHL.
- Larger studies are required to confirm the role of MTHFR polymorphisms in SHL etiology.