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Acute marijuana effects on human risk taking.

Scott D Lane1, Don R Cherek, Oleg V Tcheremissine

  • 1Department of Psychiatry & Behavioral Sciences, University of Texas Health Science Center, Houston, TX 77030, USA. scott.d.lane@uth.tmc.edu

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|March 19, 2005
PubMed
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Marijuana use, specifically higher doses of THC, increased risky decision-making in a laboratory setting. This suggests altered sensitivity to consequences may drive drug-induced risk-taking behaviors.

Area of Science:

  • Psychopharmacology
  • Behavioral Neuroscience

Background:

  • Previous research links marijuana use to increased risky behavior in real-world settings.
  • Laboratory studies on marijuana's acute effects on risk-taking are limited.

Purpose of the Study:

  • To investigate the acute effects of smoked marijuana on human risk-taking behavior in a controlled laboratory environment.
  • To identify potential behavioral mechanisms underlying marijuana-induced alterations in risk-taking probability.

Main Methods:

  • A within-subject, repeated-measures design was employed with 10 adult participants.
  • Participants received placebo and three doses of marijuana cigarettes (varying Delta9-THC content: 0%, 1.77%, 3.58%).
  • A laboratory risk-taking task assessed choices between risky and non-risky options, alongside physiological and subjective measures.

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Main Results:

  • The highest dose (3.58% Delta9-THC) significantly increased the selection of the risky response option.
  • This dose also altered response probabilities following both positive and negative outcomes associated with the risky choice.
  • Findings indicate measurable changes in risky decision-making under acute marijuana administration.

Conclusions:

  • Acute marijuana administration, particularly at higher THC concentrations, can measurably alter risky decision-making in a laboratory context.
  • Altered sensitivity to the consequences of risky choices may be a key mechanism driving these drug-induced behavioral changes.
  • The study discusses potential neurobiological targets of THC involved in these observed effects.