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Limited dissection of abdominal aortic aneurysm in a patient with multiple myeloma
Hisato Takagi1, Yoshio Mori, Yukio Umeda
1First Department of Surgery, Gifu University School of Medicine, Tsukasa, Gifu, Japan. h-takagi@cc.gifu-u.ac.jp
Abstract:
Dissection limited to the abdominal aorta contributes 4% of all aortic dissections, and inflammatory injury of the aortic media is one of factors associated with dissection. In multiple myeloma, leukocytoclastic vasculitis of the skin has been known. We describe limited dissection of an abdominal aortic aneurysm with dense lymphocyte infiltration in a 62-year-old man with multiple myeloma. Although it is unclear whether the lymphocyte infiltration in the aortic wall, which was denser than that of atherosclerotic aneurysm, was associated with multiple myeloma, the excessive aortic wall inflammation may have somewhat influenced aneurysm formation or aortic dissection.
Insights
Abdominal aortic dissection is rare, but inflammation may play a role. This case study explores a link between multiple myeloma and aortic dissection with dense lymphocyte infiltration, suggesting inflammation
Area of Science:
- Cardiovascular Medicine
- Hematology
- Pathology
Background:
- Abdominal aortic dissection (AAD) accounts for 4% of all aortic dissections.
- Inflammatory injury to the aortic media is a known factor in aortic dissection.
- Leukocytoclastic vasculitis is a recognized manifestation of multiple myeloma in the skin.
Observation:
- A 62-year-old male patient with multiple myeloma presented with limited dissection of an abdominal aortic aneurysm.
- The resected aortic aneurysm showed dense lymphocyte infiltration.
- The aortic wall inflammation was notably denser than typically observed in atherosclerotic aneurysms.
Findings:
- The study describes a rare case of abdominal aortic aneurysm dissection in a patient with multiple myeloma.
- Dense lymphocyte infiltration was observed in the aortic wall, suggesting significant inflammation.
- The precise association between the lymphocyte infiltration and multiple myeloma remains unclear.
Implications:
- Excessive aortic wall inflammation may contribute to the formation of abdominal aortic aneurysms and subsequent dissection.
- This case highlights a potential, though unconfirmed, link between multiple myeloma and aortic pathology.
- Further research is needed to elucidate the role of systemic inflammation in aortic aneurysm development and dissection.
