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Lanomycin and glucolanomycin, antifungal agents produced by Pycnidiophora dispersa. I. Discovery, isolation and
J O'Sullivan1, D W Phillipson, D R Kirsch
1Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, N.J. 08543-4000.
The Journal of Antibiotics
|March 1, 1992
Abstract:
The antifungal agents lanomycin and glucolanomycin were isolated from Pycnidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-450 enzyme lanosterol 14 alpha-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents.