Synthesis and antitumor activity of 4'-O-acylanthracyclines
S Nakajima1, H Kawai, N Komeshima
1Pharmaceutical Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
The Journal of Antibiotics
|March 1, 1992
Abstract:
4'-O-Acyl derivatives of doxorubicin, daunorubicin, 13-deoxocarminomycin, 13-deoxo-10-hydroxycarminomycin, 13-deoxo-11-deoxycarminomycin were synthesized through the formation and mild acid hydrolysis of 2-oxazoline intermediates. The antitumor activity of these 4'-O-acyl derivatives against P388 leukemia was similar to or more effective than the parent anthracyclines.
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