The binary eutectic of NSAIDS and two-phase liquid system for enhanced membrane permeation
1Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, Georgia 30602, USA.
Pharmaceutical Development and Technology
|March 22, 2005
Summary
Eutectic mixtures of nonsteroidal anti-inflammatory drugs (NSAIDs) with ibuprofen significantly lower melting points. This eutectic formation enhances drug permeation through membranes, offering a novel delivery approach.
Area of Science:
- Pharmaceutical Sciences
- Physical Chemistry
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
- Improving the membrane permeation of NSAIDs is crucial for effective drug delivery.
Purpose of the Study:
- To investigate the eutectic properties of binary NSAID-ibuprofen mixtures.
- To evaluate the impact of eutectic formation on the membrane permeation of ketoprofen and ibuprofen.
Main Methods:
- Differential scanning calorimetry (DSC) and phase equilibrium diagrams were used to study eutectic properties.
- Franz diffusion cells with snake skin as a model membrane were employed to assess permeation rates.
Main Results:
- Binary eutectic formation significantly depressed the melting points of NSAIDs with ibuprofen.
- A two-phase liquid system formed with aqueous isopropyl alcohol (IPA) facilitated high drug concentrations in the oily phase.
- Enhanced membrane permeation rates were observed for ibuprofen (37.5 microg/cm2/hr) and ketoprofen (33.4 microg/cm2/hr).
Conclusions:
- Eutectic formation with ibuprofen offers a promising strategy for enhancing NSAID membrane permeation.
- The developed two-phase liquid system demonstrates potential for improved drug delivery applications.
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