Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autonomic nervous system dysfunction in multiple sclerosis patients.

M Brezinova1, Z Goldenberg, P Kucera

  • 11st Department of Neurology, University Hospital and Faculty of Medicine, Comenius University, Bratislava, Slovakia. brezina.maria@zoznam.sk

Bratislavske Lekarske Listy
|March 22, 2005
PubMed
Summary

Autonomic nervous system (ANS) dysfunction is present in multiple sclerosis (MS) patients, indicated by altered heart rate variability during deep breathing and spectral analysis. These findings highlight ANS involvement in MS progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of semi-quantitative and visual assessment of early MRI signal evolution in acute ischaemic stroke.

European journal of radiology open·2023
Same author

Pilot study trialling a new ambulatory method for the clinical assessment of regional gastrointestinal transit using multiple electromagnetic capsules.

Neurogastroenterology and motility·2014
Same author

Mutations in HINT1 are one of the most frequent causes of hereditary neuropathy among Czech patients and neuromyotonia is rather an underdiagnosed symptom.

Neurogenetics·2014
Same author

Transient ischemic attack in the vertebro-basilar circulation due to a hemodynamically significant variation - kinking of the extracranial section of the left vertebral artery.

Bratislavske lekarske listy·2013
Same author

Positivity for islet cell autoantibodies in patients with monogenic diabetes is associated with later diabetes onset and higher HbA1c level.

Diabetic medicine : a journal of the British Diabetic Association·2013
Same author

Validation of whole chick embryo cultures, whole rat embryo cultures and aggregating embryonic brain cell cultures using six pairs of coded compounds.

Toxicology in vitro : an international journal published in association with BIBRA·2010

Area of Science:

  • Neurology
  • Cardiology
  • Autonomic Neuroscience

Background:

  • Multiple sclerosis (MS) is a chronic demyelinating disease affecting the central nervous system.
  • Autonomic nervous system (ANS) dysfunction is increasingly recognized as a complication in MS patients.
  • Cardiovascular reflex and heart rate variability assessments are crucial for evaluating ANS function.

Purpose of the Study:

  • To investigate autonomic nervous system (ANS) function in multiple sclerosis (MS) patients.
  • To compare ANS function between MS patients and healthy controls using cardiovascular reflex tests and heart rate variability analysis.
  • To identify specific ANS impairments associated with MS.

Main Methods:

  • Conducted cardiovascular reflex examinations, including deep breathing tests (I/E, I-E indices) and active standing tests (RRmax/RRmin).

Related Experiment Videos

  • Performed spectral analysis of heart rate variability (HRV) in very low (VLF), low (LF), and high (HF) frequency bands.
  • Evaluated 36 patients diagnosed with multiple sclerosis (MS) and compared results with a healthy control group.

    • Main Results:

    • MS patients showed a significant difference in the I-E index during deep breathing tests compared to controls.
    • No significant differences were observed in the I/E index (deep breathing) or RRmax/RRmin (active standing) between MS patients and controls.
    • Spectral analysis of HRV revealed significant differences in all frequency bands (VLF, LF, HF) in MS patients compared to healthy individuals.

    Conclusions:

    • Autonomic nervous system (ANS) dysfunction, particularly related to parasympathetic activity, is evident in multiple sclerosis (MS) patients.
    • Heart rate variability spectral analysis is a sensitive tool for detecting ANS alterations in MS.
    • These findings underscore the importance of assessing ANS function in the comprehensive management of MS.