Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel integrin antagonists derived from thrombospondins.

Maria J Calzada1, David D Roberts

  • 1Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Current Pharmaceutical Design
|March 22, 2005
PubMed
Summary

Researchers identified novel recognition motifs for integrins alpha3beta1 and alpha6beta1, crucial for understanding angiogenesis. These findings pave the way for developing new antagonists targeting pathological angiogenesis and other diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncovering the Role of Thrombospodin-1 and Occludin as Potential Prognostic and Diagnostic Biomarkers in Traumatic Brain Injury.

International journal of molecular sciences·2026
Same author

T Cell Activation Induces Synthesis of CD47 Proteoglycan Isoforms and Their Release in Extracellular Vesicles.

International journal of molecular sciences·2025
Same author

Uncovering a novel role of nAChRs in oxidative stress-mediated vascular dysfunction in COPD.

Redox biology·2025
Same author

Oxidative Stress and Inflammation in Hypoxemic Respiratory Diseases and Their Comorbidities: Molecular Insights and Diagnostic Advances in Chronic Obstructive Pulmonary Disease and Sleep Apnea.

Antioxidants (Basel, Switzerland)·2025
Same author

CSE-Induced ER-Mitochondria Crosstalk Promotes Oxidative Stress and Impairs Bronchial Contractile Response.

Antioxidants (Basel, Switzerland)·2025
Same author

<i>CD47</i> and <i>IFT57</i> Are Colinear Genes That Are Highly Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific Correlations with Survival.

International journal of molecular sciences·2024

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Medicine

Background:

  • Integrins are key cell surface receptors involved in various physiological processes.
  • Current research focuses on integrin antagonists for cancer, thrombosis, and inflammation.
  • Limited knowledge of recognition motifs hinders the development of specific integrin antagonists.

Purpose of the Study:

  • To identify novel recognition motifs for integrins alpha3beta1 and alpha6beta1.
  • To explore the roles of integrins alpha3beta1, alpha6beta1, and alpha4beta1 in angiogenesis.
  • To discuss the therapeutic potential of integrin antagonists in controlling pathological angiogenesis.

Main Methods:

  • Studied thrombospondin-1 and thrombospondin-2 interactions with integrins.

Related Experiment Videos

  • Investigated recognition motifs for alpha3beta1, alpha6beta1, and alpha4beta1 integrins.
  • Reviewed existing literature on integrin function and antagonist development.

    • Main Results:

    • Discovered novel recognition motifs for alpha3beta1 and alpha6beta1 integrins.
    • Identified new motifs recognized by the alpha4beta1 integrin.
    • Highlighted distinct roles of these integrins in angiogenesis modulation.

    Conclusions:

    • Novel motifs for alpha3beta1 and alpha6beta1 integrins offer new therapeutic targets.
    • Antagonists targeting alpha3beta1, alpha6beta1, and alpha4beta1 may control pathological angiogenesis.
    • Further research into integrin specificities can lead to novel disease interventions.