Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Collagen-binding integrins as pharmaceutical targets.

Johannes A Eble1

  • 1Institute for Physiological Chemistry and Pathobiochemistry, Muenster University Hospital, Waldeyerstr. 15, 48149 Muenster, Germany. eble@uni-muenster.de

Current Pharmaceutical Design
|March 22, 2005
PubMed
Summary

Advances in structural biology reveal how collagens bind to integrin receptors. This knowledge aids in developing drugs targeting collagen-binding integrins for various diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective degradation of platelet BTK by PROTAC NX-5948 provides antithrombotic benefits without affecting haemostasis.

Blood advances·2026
Same author

The Plasma Glycoprotein Milieu in the Hemato-Oncological Patient Inhibits Platelet Function.

Biomolecules·2026
Same author

Neuwlectin, a novel C-type lectin from Bothrops neuwiedi venom, inhibits platelet aggregation induced by cancer cells and angiogenesis.

Biochimie·2026
Same author

VE-Cadherin-Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension-Sensitive Intermediate State.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Comparison of proteomes and biofunctional properties of male and female common adder (Vipera berus) venoms.

Biochimie·2026
Same author

A novel ABCA1 variant associated with impaired platelet production contributing to thrombocytopenia in a family with Tangier disease.

Journal of clinical lipidology·2026

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Significant progress has been made in understanding collagen-integrin interactions.
  • Structural studies of integrins and collagenous triple helices have been crucial.
  • The tissue distribution and functions of collagen-binding integrins are increasingly understood.

Purpose of the Study:

  • To elucidate the molecular mechanisms of collagen-integrin binding.
  • To understand the role of collagen-binding integrins in physiological and pathological processes.
  • To facilitate the development of therapeutic agents targeting collagen-binding integrins.

Main Methods:

  • Crystallographic analysis of integrin ectodomains and A-domains.
  • Structural determination of integrin A-domain:collagen complexes.

Related Experiment Videos

  • Characterization of tissue distribution and biological functions of integrins.
  • Chemical synthesis of collagenous triple helices.

    • Main Results:

    • Resolved structures of integrin ectodomains, A-domains, and their collagen complexes.
    • Provided molecular insights into integrin-collagen interactions and signal transduction.
    • Identified the involvement of specific integrins (e.g., alpha2beta1) in platelet activation and inflammation.
    • Demonstrated the potential for developing collagen-mimicking compounds as agonists or antagonists.

    Conclusions:

    • Structural insights into integrin-collagen interactions are key to understanding cellular signaling.
    • Collagen-binding integrins play critical roles in platelet aggregation and inflammatory processes.
    • Knowledge of these interactions enables the rational design of novel therapeutics targeting collagen-binding integrins.