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Tolerability of moxifloxacin in patients with antibiotic hypersensitivity

B Bozkurt1, G Karakaya, A F Kalyoncu

  • 1Department of Chest Diseases, Hacettepe University, School of Medicine, Sihhiye Ankara, Turkey. bubozkur@hacettepe.edu.tr

Allergologia Et Immunopathologia
|March 22, 2005
PubMed
Abstract

Insights

Moxifloxacin, a new fluoroquinolone, was well-tolerated by most patients with antibiotic hypersensitivity (AH). This suggests moxifloxacin may be a safe alternative for individuals allergic to other antibiotics.

Area of Science:

  • Clinical immunology
  • Pharmacology
  • Infectious diseases

Background:

  • Antibiotic hypersensitivity (AH) is common, necessitating alternative treatments.
  • Oral provocation tests (OPT) identify safe antibiotics.
  • Moxifloxacin, a broad-spectrum fluoroquinolone, has rarely been associated with allergic reactions.

Purpose of the Study:

  • To evaluate the tolerability of moxifloxacin in patients with diagnosed antibiotic hypersensitivity.

Main Methods:

  • A prospective study involved 20 patients with AH.
  • A single-blind, one-day oral provocation test (OPT) protocol for moxifloxacin was administered.
  • Patients received a total dose of 1000 mg of moxifloxacin.

Main Results:

  • 17 out of 20 patients (85%) tolerated moxifloxacin without adverse events.
  • One patient experienced transient generalized urticaria.
  • Another patient had temporary tachycardia, and a third reported transient nausea.

Conclusions:

  • Moxifloxacin demonstrates high tolerability in patients with antibiotic hypersensitivity.
  • It may serve as a viable therapeutic alternative, especially for those with beta-lactam allergies.

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