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Does gene therapy become pharmacotherapy?

Ryuichi Morishita1, Motokuni Aoki, Toshio Ogihara

  • 1Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita 565-0871, Japan. morishit@cgt.med.osaka-u.ac.jp

Experimental Physiology
|March 22, 2005
PubMed
Summary

Gene therapy shows promise for treating cardiovascular diseases like peripheral arterial disease and ischaemic heart disease, offering a potential future pharmacotherapy despite current limitations.

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Area of Science:

  • Cardiovascular Medicine
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Effective cardiovascular drugs exist, but significant unmet needs remain for diseases such as peripheral arterial disease, ischaemic heart disease, restenosis, and graft occlusion.
  • Gene therapy is emerging as a promising strategy to address these challenging cardiovascular conditions.

Purpose of the Study:

  • To review the current status and future potential of gene therapy for cardiovascular disease treatment.
  • To highlight the evolution of gene therapy applications in cardiovascular medicine since the first human trial in 1994.

Main Methods:

  • Review of clinical trials and research on gene therapy for cardiovascular diseases.
  • Focus on angiogenic growth factors, including vascular endothelial growth factor (VEGF).

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Main Results:

  • Gene therapy trials have shown improvements in clinical symptoms for peripheral arterial disease and ischaemic heart disease.
  • Various potent angiogenic growth factors have been investigated in clinical settings.

Conclusions:

  • Gene therapy has demonstrated potential in treating specific cardiovascular diseases.
  • Further development may establish gene therapy as a viable pharmacotherapy for cardiovascular disease in the future.