The LundADose method for planar image activity quantification and absorbed-dose assessment in radionuclide therapy

Area of Science:

• Medical Physics
• Nuclear Medicine
• Radiotherapy Dosimetry

Background:

• Accurate absorbed-dose assessment is crucial for effective radionuclide therapy.
• Previous methods for activity quantification had limitations in complex scenarios.
• Advancements in imaging technology necessitate updated dosimetric approaches.

Purpose of the Study:

• To present a novel, automated method for absorbed-dose assessment in radionuclide therapy.
• To enhance activity quantification using conjugate-view methodology with advanced corrections.
• To integrate new dual-head camera capabilities and time-activity modeling into dosimetric calculations.

Main Methods:

• Utilized conjugate-view methodology on serial whole-body scintillation-camera scans.
• Implemented corrections for attenuation, scatter, and overlapping organs.
• Integrated dual-head camera X-ray imaging, time-activity modeling, and Medical Internal Radiation Dose (MIRD) formalism.
• Developed the LundADose software for automated quantification, image registration, and dose calculation.

Main Results:

• The LundADose program streamlines absorbed-dose assessments for numerous patient studies.
• The method was evaluated for whole-body activity quantification in radioimmunotherapy patients.
• Demonstrated feasibility for monoclonal antibodies labeled with Indium-111 ((111)In) or Yttrium-90 ((90)Y).

Conclusions:

• The LundADose system offers an automated and comprehensive approach to absorbed-dose assessment in radionuclide therapy.
• The enhanced quantification method improves accuracy by accounting for various physical factors and advanced imaging.
• This facilitates more precise dosimetry for personalized patient treatment in nuclear medicine.