Hepatitis B vaccination in a school age population: a feasibility study

Area of Science:

• Public Health
• Vaccinology
• Epidemiology

Background:

• The UK has low endemicity of hepatitis B virus (HBV).
• A universal hepatitis B vaccination strategy for the general population is not yet established.
• Adolescent vaccination is being considered as a potential public health approach.

Purpose of the Study:

• To evaluate the feasibility and acceptance of a school-based hepatitis B vaccination program for adolescents aged 11-13 years.
• To assess the uptake and completion rates of a three-dose hepatitis B vaccine regimen in a school setting.

Main Methods:

• A prospective study was conducted in secondary schools in Camden and Islington, London.
• 11-13 year old pupils were offered a three-dose hepatitis B vaccination (Engerix B) using a 0, 1, and 12 months schedule.
• Vaccine acceptance, completion rates, and reasons for non-vaccination were recorded.

Main Results:

• Out of 528 pupils contacted, 122 (23%) consented to vaccination.
• 117 (96%) of those who consented completed the full three-dose regimen.
• High rates of vaccine completion were achieved among consenting adolescents.

Conclusions:

• School-based hepatitis B vaccination for adolescents is feasible and practical in the UK.
• Achieving high vaccination coverage requires comprehensive health promotion and robust school health support.
• Targeting teachers, pupils, and parents is crucial for increasing participation in adolescent vaccination programs.