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Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

BCG vaccine-associated suppurative lymphadenitis.

Stephen S S Teo¹, Naima Smeulders, Delane V Shingadia

¹Centre for Child Health, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, 38 New Road, London E1 2AX, UK.

|March 23, 2005

Summary

Clusters of suppurative lymphadenitis linked to the BCG vaccine (BCG-ASLD) have increased. This rise followed a switch from the Evans vaccine to the intradermal BCG Statens Serum Institute (SSI) vaccine.

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Area of Science:

Immunology
Vaccinology
Pediatrics

Background:

BCG vaccination is crucial for preventing tuberculosis.
Clusters of BCG vaccine-associated suppurative lymphadenitis (BCG-ASLD) are a known complication.
Recent observations indicate a potential increase in BCG-ASLD cases.

Purpose of the Study:

To investigate the association between a specific BCG vaccine formulation and BCG-ASLD.
To analyze trends in BCG-ASLD following a vaccine change.

Main Methods:

Retrospective analysis of BCG-ASLD cases.
Comparison of incidence rates before and after vaccine switch.
Identification of vaccine type used (percutaneous Evans vs. intradermal SSI).

Main Results:

An increase in BCG-ASLD clusters was observed.
The rise in BCG-ASLD coincided with the introduction of the intradermal BCG SSI vaccine.
A shift from percutaneous Evans vaccine to intradermal BCG SSI vaccine was documented.

Conclusions:

The change in BCG vaccine formulation may be associated with an increased risk of BCG-ASLD.
Further investigation into vaccine-specific risks is warranted.
Monitoring BCG-ASLD incidence is essential following vaccine changes.