Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Buprenorphine: considerations for pain management.

Rolley E Johnson1, Paul J Fudala, Richard Payne

  • 1Department of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Journal of Pain and Symptom Management
|March 23, 2005
PubMed
Summary

Buprenorphine, a partial mu-opioid agonist, offers a ceiling effect that may reduce abuse potential and improve safety for pain management. It is effective for various pain types and opioid addiction, with milder withdrawal than full agonists.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Renal Autologous Cell Therapy to Stabilize Function in Diabetes-Related Chronic Kidney Disease: Corroboration of Mechanistic Action With Cell Marker Analysis" [<i>Kidney International Reports</i> Volume 7, Issue 7, July 2022, Pages 1619-1629].

Kidney international reports·2026
Same author

Malignancy Risk, Molecular Mutations, and Surgical Outcomes of Thyroid Nodules Classified as Atypia of Undetermined Significance in the Bethesda System: A Comprehensive Analysis.

Cytopathology : official journal of the British Society for Clinical Cytology·2025
Same author

Characteristics and Prognostic Markers of Aggressive Subtypes of Thyroid Cancer: A Retrospective Study.

Cancer reports (Hoboken, N.J.)·2025
Same author

Climate Effects on Belowground Tea Litter Decomposition Depend on Ecosystem and Organic Matter Types in Global Wetlands.

Environmental science & technology·2024
Same author

Effect of neutering timing in relation to puberty on health in the female dog-a scoping review.

PloS one·2024
Same author

Assessing the Performance of Machine Learning Methods Trained on Public Health Observational Data: A Case Study From COVID-19.

Statistics in medicine·2024

Area of Science:

  • Pharmacology
  • Pain Management
  • Addiction Treatment

Background:

  • Effective analgesics are crucial for pain management.
  • Buprenorphine, a partial mu-opioid agonist, has a long clinical history.
  • Its unique profile supports novel formulation development.

Purpose of the Study:

  • To review the utility of buprenorphine in pain management.
  • To explore its potential for new formulations.
  • To discuss its safety and abuse profile.

Main Methods:

  • Literature review of buprenorphine's properties and applications.
  • Analysis of its pharmacological and physiochemical characteristics.
  • Examination of clinical use in pain, anesthesia, and addiction.

Related Experiment Videos

Main Results:

  • Buprenorphine exhibits a dose-ceiling effect on physiological and subjective responses, potentially limiting abuse.
  • It is available in parenteral, sublingual, and transdermal formulations.
  • Clinical applications include acute/chronic pain, anesthesia, and opioid addiction treatment.

Conclusions:

  • Buprenorphine's formulation flexibility and safety profile make it a valuable analgesic option.
  • Its partial agonism may offer a wider safety margin compared to full mu-opioid agonists.
  • While dependence can occur, withdrawal is generally less severe than with full agonists.