Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Current chemotherapy for tuberculosis in children.

¹Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Infectious Disease Clinics of North America

|March 1, 1992

Summary

Short-course chemotherapy for pediatric tuberculosis is highly effective and well-tolerated. Newer regimens offer faster action, reduced relapse, and better coverage for drug-resistant tuberculosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical standards for drug-susceptible TB in children and adolescents.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023

Same author

Administration and monitoring of clofazimine for NTM infections in children with and without cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2021

Same author

Epidemiology and clinical characteristics of childhood TB identified using active and passive case finding.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021

Same author

Global shortages of BCG vaccine and tuberculous meningitis in children.

The Lancet. Global health·2018

Same author

Controversies in tuberculous infection among pediatric infectious disease specialists in North America.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2016

Same author

Safety and completion of a 4-month course of rifampicin for latent tuberculous infection in children.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2014

Area of Science:

Pediatric Infectious Diseases
Pulmonology
Pharmacology

Background:

Antituberculosis medications demonstrate excellent tolerability and efficacy in children.
Short-course chemotherapy regimens offer significant advantages over traditional treatments for pediatric tuberculosis.

Purpose of the Study:

To outline current recommendations for treating tuberculosis in children.
To highlight the benefits of newer chemotherapy regimens.
To address challenges in pediatric tuberculosis treatment adherence.

Main Methods:

Review of current guidelines for pediatric tuberculosis treatment.
Description of recommended 6-month regimens including isoniazid, rifampin, and pyrazinamide.
Discussion of treatment administration (daily vs. twice-weekly) and duration based on clinical presentation and adherence.

Main Results:

The standard regimen involves 6 months of isoniazid and rifampin, with pyrazinamide for the first 2 months.
Daily or twice-weekly administration is recommended, with direct observation crucial for adherence.
Extended durations (6-12 months) may be necessary for tuberculous meningitis and in cases of non-adherence.

Conclusions:

Current short-course chemotherapy regimens are effective and well-tolerated for pediatric tuberculosis.
Ensuring patient adherence is critical for successful tuberculosis control in children.
Healthcare providers must actively manage adherence to optimize treatment outcomes.

Related Experiment Videos