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T cell aging: naive but not young

Janko Nikolich-Zugich1

  • 1Oregon Health and Science University, Beaverton, OR 97006, USA. nikolich@ohsu.edu

The Journal of Experimental Medicine
|March 23, 2005
PubMed

The immune system exhibits profound age-related changes, collectively termed immunosenescence. The most visible of these is the decline in protective immunity, which results from a complex interaction of primary immune defects and compensatory homeostatic mechanisms. The sum of these changes is a dysregulation of many processes that normally ensure optimal immune function. Recent advances suggest that old mice can produce fully functional new T cells, opening both intriguing inquiry avenues and raising critical questions to be pursued.

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