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Updated: Aug 19, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Sonothrombolysis in acute ischemic stroke for patients ineligible for rt-PA
Jürgen Eggers1, Günter Seidel, Björn Koch
1Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Abstract:
The authors studied the effect of transcranial ultrasound on patients with acute middle cerebral artery occlusion and contraindications for thrombolysis. Fifteen consecutive subjects were randomized for insonation over 1 hour or for inclusion in a control group. By day 4, recanalization and neurologic improvement occurred more frequently in the target group. Ultrasound-induced acceleration of clot dissolution may be an option for patients with contraindications for recombinant tissue plasminogen activator.
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