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Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen
S U Schuele1, C Kellinghaus, S J Shook
1Department of Neurology/S91, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. schules@ccf.org
Abstract:
Oral and intrathecal baclofen (ITB) have been associated with epileptic seizures. The authors observed a higher incidence of epileptic seizures in 99 patients with multiple sclerosis (MS) treated with ITB vs a matched control group (7% vs 1%, p < 0.05). Three patients with MS on ITB developed status epilepticus. Seizures were often associated with additional triggering factors.
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