Related Experiment Video
Updated: Aug 19, 2026

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
Regulation of inducible nitric oxide synthase by aggresome formation
Katarzyna E Kolodziejska1, Alan R Burns, Robert H Moore
1Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Abstract:
Misfolding and aggregation of proteins play an important part in the pathogenesis of several genetic and degenerative diseases. Recent evidence suggests that cells have evolved a pathway that involves sequestration of aggregated proteins into specialized "holding stations" called aggresomes. Here we show that cells regulate inducible NO synthase (iNOS), an important host defense protein, through aggresome formation. iNOS aggresome formation depends on a functional dynein motor and the integrity of the microtubules. The iNOS aggresome represents a "physiologic aggresome" and thus defines a new paradigm for cellular regulation of protein processing. This study indicates that aggresome formation in response to misfolded proteins may merely represent an acceleration of an established physiologic regulatory process for specific proteins whose regulation by aggresome formation is deemed necessary by the cell.
More Related Videos
Related Concept Videos
Nitric Oxide Signaling Pathway
Regulation of Nuclear Protein Sorting
Regulation of the Unfolded Protein Response
Inorganic Nitrogen Assimilation
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Regulation of Expression at Multiple Steps

