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No go for brain tumors?
Felicia Yu Hsuan Teng1, Bor Luen Tang
1Department of Biochemistry and Programme in Neurobiology and Aging, National University of Singapore, Singapore 117597, Republic of Singapore.
Abstract:
The Nogo gene and its products are well known as adult central nervous system (CNS) myelin inhibitors of neuronal regeneration. We review here experimental findings that might link Nogo to CNS malignancy. These links are founded on two very different modes of cellular action by Nogo isoforms. Acting intracellularly and in conjunction with other molecules, cytoplasmic domains of Nogo might predispose cancer cells to apoptotic susceptibility. On the other hand, extracellular domains of Nogo might inhibit the migration and invasion of CNS tumors. Depending on the physiological context, Nogo isoforms might therefore be antitumorigenic or have tumor-suppressing activities.
Insights
Nogo gene products, known CNS myelin inhibitors, may impact cancer. Depending on their location, Nogo isoforms can either promote cancer cell death or suppress tumor growth and spread.
Area of Science:
- Neuroscience
- Oncology
- Molecular Biology
Background:
- Nogo gene products are established inhibitors of neuronal regeneration in the adult central nervous system (CNS).
- Emerging evidence suggests a potential role for Nogo in central nervous system (CNS) malignancy.
Purpose of the Study:
- To review experimental findings linking Nogo gene products to CNS malignancy.
- To explore the dual role of Nogo isoforms in cancer based on their cellular action.
Main Methods:
- Literature review of experimental findings on Nogo gene products and CNS malignancy.
- Analysis of Nogo isoform functions based on intracellular and extracellular domains.
Main Results:
- Intracellular Nogo domains, with other molecules, may increase cancer cell susceptibility to apoptosis.
- Extracellular Nogo domains may inhibit the migration and invasion of CNS tumors.
Conclusions:
- Nogo isoforms exhibit context-dependent activities in CNS malignancy.
- Nogo may possess both antitumorigenic and tumor-suppressing properties in the central nervous system.
