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Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction

Cui-Wei Xie1

  • 1Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095-1761, USA. cxie@mednet.ucla.edu

Neuromolecular Medicine
|March 23, 2005
PubMed
Summary

Amyloid beta peptides disrupt synaptic plasticity in Alzheimer's disease (AD) models by altering calcium signaling. These disruptions in calcium-regulated pathways contribute to early synaptic dysfunction in AD.

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