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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Outcome of endovascular treatment in symptomatic intracranial vascular stenosis
Dae Chul Suh1, Sang Joon Kim, Duk Hee Lee
1Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. dcsuh@www.amc.seoul.kr
Insights
This study shows that intracranial angioplasty and/or stenting for severe stenosis is highly successful, with a low rate of symptomatic recurrence. Physicians should remain aware of potential, though rare, fatal complications during these procedures.
Area of Science:
- Neurology
- Interventional Neuroradiology
- Vascular Surgery
Background:
- Revascularization of intracranial vascular stenoses is technically demanding, with limited outcome data.
- Symptomatic severe intracranial stenosis poses a significant risk of cerebrovascular events.
Purpose of the Study:
- To evaluate the early and late clinical outcomes of angioplasty and/or stenting for symptomatic severe intracranial vascular stenoses.
- To assess angiographic success, periprocedural complications, and long-term recurrence rates.
Main Methods:
- Retrospective analysis of 35 patients treated between 1995 and an unspecified end date.
- Procedures included angioplasty (n=19) or stenting (n=16) for stenoses >70% in the middle cerebral artery, basilar artery, vertebral artery, and internal carotid artery.
- Outcomes assessed included angiographic success (<50% residual stenosis), periprocedural complications (30-day), and symptomatic recurrence/restenosis (mean 22-month follow-up).
Main Results:
- High angiographic success rate of 97% (34/35 patients).
- Periprocedural complication rate of 11% (4/35 patients), including one death and one minor stroke.
- Mean follow-up of 22 months showed asymptomatic restenosis in 9% and symptomatic restenosis in 6% of target lesions.
Conclusions:
- Intracranial angioplasty and/or stenting achieves high angiographic success with an acceptable complication rate.
- The procedure demonstrates a relatively low rate of symptomatic recurrence for intracranial vascular stenoses.
- Physicians must be aware of the potential for rare but fatal periprocedural complications, such as hemorrhage.
Objective:
The outcome evaluation for the revascularization of intracranial vascular stenoses has not been fully described due to the highly technical nature of the procedure. We report here on the early and late clinical outcomes of angioplasty and/or stenting of symptomatic severe intracranial vascular stenoses at a single institute.
Materials And Methods:
Since 1995, we have treated 35 patients with symptomatic intracranial vascular stenosis (more than 70% stenosis, mean stenosis: 78.6%+/-6.2%). Angioplasty (n = 19) was performed for the horizontal segment of the middle cerebral artery (M1) (n = 16) and the basilar artery (BA) (n = 1), the intradural vertebral artery (VA) (n = 1), and the cavernous internal carotid artery (ICA) (n = 1). Stenting (n = 16) was performed for the cavernous or petrous ICAs (n = 9), the intradural VA (n = 3), BA (n = 2), and M1 (n = 2) artery. We assessed the angiographic success (defined as residual stenosis < 50%) rate, the periprocedural complications during the 30-day periprocedural period, the symptomatic recurrence and restenosis during a mean 22-month follow-up (FU) period. The Kaplan-Meier estimate of the cumulative event-free rate of the major cerebrovascular events, i.e. death, stroke or restenosis, was also done.
Results:
Angiographic success was achieved in 97% of our patients (34/35). There were four procedure-related complications (11%) including a death and a minor stroke. During the mean 22-month FU, the asymptomatic restenosis rate was 9% and the symptomatic restenosis rate was 6% in the target lesion and 9% in all the vascular territories. The Kaplan-Meier estimate was 70.6% (95% confidence interval = 46.5-94.7) after 33 months of FU.
Conclusion:
In addition to a high angiographic success rate and an acceptable periprocedural complication rate, intracranial angioplasty and/or stenting revealed a relatively low symptomatic recurrence rate. Hemorrhage is a rare, but the physician must aware that potentially fatal periprocedural complications can occur.
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