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Renal function during and after treatment for acute lymphoblastic leukemia in children

Maryna Krawczuk-Rybak1, Marta Kuźmicz, Jolanta Wysocka

  • 1Department of Pediatric Oncology, Medical University of Białystok, Poland. rybak@AMB.edu.pl

Pediatric Nephrology (Berlin, Germany)
|March 23, 2005
PubMed

Insights

This study found that combined treatment for acute lymphoblastic leukemia (ALL) generally does not cause severe or long-term kidney problems in children. Renal function tests remained within normal ranges for most patients during and after ALL treatment.

Area of Science:

  • Pediatric Oncology
  • Nephrology
  • Hematology

Background:

  • Acute lymphoblastic leukemia (ALL) treatment involves complex protocols that may affect organ function.
  • Monitoring renal function is crucial in pediatric cancer patients undergoing chemotherapy.

Purpose of the Study:

  • To evaluate renal function in children diagnosed with and treated for ALL.
  • To assess long-term effects of ALL treatment on kidney health.

Main Methods:

  • Renal function tests including cystatin C, creatinine, beta(2)-microglobulin, microalbuminuria, and osmolality were performed.
  • Patients were assessed at diagnosis, during treatment, and years post-treatment.
  • Results were compared to a control group of healthy children.

Main Results:

  • Mean values for renal function tests were within normal ranges for ALL patients compared to controls.
  • Transient, normal-range increases in cystatin C were noted post-methotrexate and post-treatment.
  • A small number of children experienced temporary or prior renal function decline.

Conclusions:

  • Combined ALL treatment is not typically associated with severe or lasting renal impairment in children.
  • Routine monitoring of renal function is important, especially considering potential transient changes.

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