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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Growth hormone for children with chronic renal failure and on dialysis

Jameela A Kari1, Lesley Rees

  • 1Pediatrics Department, King AbdulAziz University Hospital, PO Box 80215, 21589, Jeddah, Saudi Arabia. jkari@doctors.org.uk

Pediatric Nephrology (Berlin, Germany)
|March 23, 2005
PubMed

Insights

Recombinant human growth hormone (rhGH) improved height in children with chronic renal failure (CRF) for up to three years. Growth hormone therapy showed benefits for conservatively managed children and those on dialysis, with limited changes post-transplantation.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Growth Hormone Therapy

Background:

  • Chronic renal failure (CRF) in children often leads to growth impairment.
  • Recombinant human growth hormone (rhGH) is a potential therapeutic option for growth deficits in pediatric CRF.

Purpose of the Study:

  • To evaluate the efficacy of rhGH in improving height standard deviation score (Ht SDS) in children with CRF.
  • To assess the impact of rhGH on growth in children with CRF, stratified by management (conservative vs. dialysis).

Main Methods:

  • Retrospective analysis of 32 children with CRF treated with rhGH for over one year.
  • Comparison of Ht SDS changes in conservatively managed children versus those on hemodialysis (HD) or peritoneal dialysis (PD).

Main Results:

  • Conservatively managed children showed significant Ht SDS improvement up to 3 years (P=0.001).
  • Children on dialysis demonstrated significant Ht SDS improvement within the first year (P=0.02).
  • Post-transplantation, rhGH discontinuation resulted in minimal Ht SDS changes over 5 years.

Conclusions:

  • rhGH therapy offers a significant growth benefit for children with CRF, particularly in the conservatively managed group and during the initial year for those on dialysis.
  • The growth-promoting effects of rhGH are sustained for a limited period, with limited impact after renal transplantation.

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