Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Correlation between APOA gene polymorphism and intracranial aneurysm].

Yuan-li Zhao1, Yu-ming Sun, Shuo Wang

  • 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing 100050, China. zhaoyljt@public3.bta.net.cn

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|March 24, 2005
PubMed
Summary

A study explored the link between APOA gene pentanucleotide repeats (PNR) and intracranial aneurysms. Findings suggest a potential correlation between APOA PNR variations and aneurysm development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk stratification of delayed causative aneurysm detection and long-term outcome in angiographically negative spontaneous subarachnoid haemorrhage.

Stroke and vascular neurology·2024
Same author

Zabramski classification in predicting the occurrence of symptomatic intracerebral hemorrhage in sporadic cerebral cavernous malformations.

Journal of neurosurgery·2023
Same author

Somatic <i>GJA4</i> mutation in intracranial extra-axial cavernous hemangiomas.

Stroke and vascular neurology·2023
Same author

Simplex cerebral cavernous malformations with <i>MAP3K3</i> mutation have distinct clinical characteristics.

Frontiers in neurology·2022
Same author

China Stroke Statistics: an update on the 2019 report from the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations.

Stroke and vascular neurology·2022
Same author

Infarction Patterns and Recurrent Adverse Cerebrovascular Events in Moyamoya Disease.

Disease markers·2022

Area of Science:

  • Genetics
  • Neurology
  • Molecular Biology

Background:

  • Intracranial aneurysms are a significant cause of cerebrovascular disease.
  • Genetic factors are implicated in aneurysm pathogenesis.
  • APOA gene polymorphisms, specifically pentanucleotide repeats (PNR), are investigated for their role.

Purpose of the Study:

  • To investigate the association between APOA gene PNR polymorphism and the development of intracranial aneurysms.
  • To determine if specific APOA PNR genotypes or alleles are more prevalent in patients with intracranial aneurysms.

Main Methods:

  • Case-control study involving 58 patients with intracranial aneurysms and 58 healthy controls.
  • Polymerase chain reaction (PCR) and non-denatured polyacrylamide gel electrophoresis (PAGE) were used to analyze APOA PNR gene polymorphism.

Related Experiment Videos

  • Genotyping and allele analysis were performed on all participants.

    • Main Results:

    • Eight distinct gene types and six alleles of the APOA PNR polymorphism were identified.
    • Significant differences in sequence variations within the 5' control region of the APOA gene were observed between the aneurysm patient group and the control group.
    • Specific APOA PNR variants were found to be differentially distributed between cases and controls.

    Conclusions:

    • A potential correlation exists between the APOA gene PNR polymorphism and the genesis of intracranial aneurysms.
    • The identified sequence variations in the APOA gene may contribute to the risk of developing intracranial aneurysms.
    • Further research is warranted to elucidate the precise mechanisms underlying this association.