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From mouse genetics to human therapeutics.

Gary Peltz1, Jonathan Usuka

  • 1Roche Palo Alto, Department of Genetics and Genomics, 3431 Hillview Avenue S3-1, Palo Alto, CA 94304, USA. gary.peltz@roche.com

Current Opinion in Drug Discovery & Development
|March 24, 2005
PubMed
Summary

Genomic and genetic research, particularly using mouse models, offers insights into human diseases and drug metabolism. New computational methods accelerate genetic discovery, reducing costs and time for therapeutic development.

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Area of Science:

  • Genomics
  • Genetics
  • Pharmacology
  • Drug Development

Background:

  • Genomic and genetic research significantly impacts pharmaceutical R&D.
  • Mouse models are crucial for understanding human disease pathobiology and drug metabolism.
  • Identifying novel therapeutic targets is a key objective in drug development.

Purpose of the Study:

  • To review the impact of genomic and genetic research on pharmaceutical R&D.
  • To highlight the utility of mouse genomics and genetics in disease and drug metabolism studies.
  • To introduce a novel computational method for accelerating genetic discovery.

Main Methods:

  • Review of existing literature on genomic and genetic research in pharmaceuticals.
  • Emphasis on mouse genetic analysis for disease and drug metabolism.
  • Description of a recently developed computational method for genetic discovery.

Main Results:

  • Mouse genomics and genetics enhance understanding of human disease pathobiology.
  • These approaches aid in identifying new targets for therapeutic intervention.
  • A new computational method significantly speeds up genetic discovery and lowers costs.

Conclusions:

  • Genomic and genetic research, especially using mouse models, is vital for pharmaceutical innovation.
  • The described computational method overcomes limitations of traditional mouse genetic analysis.
  • Accelerated genetic discovery promises to improve the efficiency of developing new therapies.

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