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Updated: Aug 19, 2026

Measuring Fast Calcium Fluxes in Cardiomyocytes
Published on: November 29, 2011
Coupled dynamics of voltage and calcium in paced cardiac cells
Yohannes Shiferaw1, Daisuke Sato, Alain Karma
1Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts 02115, USA.
Abstract:
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
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